Each film-coated tablet contains:

• Bisoprolol Fumarate IP: 5.0 mg
• Excipients: q.s.

Enhanced Therapeutic Action: At 5mg strength, Bisoprolol provides more robust beta-1 receptor blockade, delivering superior cardiovascular protection. This selective beta-blocker action reduces cardiac workload more effectively while maintaining its cardioselective profile, ensuring minimal interference with respiratory and peripheral vascular function.

BISOZIO 5mg provides enhanced treatment for:

• Moderate to Severe Hypertension: For patients requiring stronger blood pressure control
• Advanced Heart Failure Management: Maintenance therapy in chronic heart failure with reduced ejection fraction
• Chronic Stable Angina: Long-term prevention of chest pain and improved exercise capacity
• Complex Arrhythmias: Management of atrial fibrillation and ventricular arrhythmias
• Post-MI Cardioprotection: Enhanced secondary prevention after myocardial infarction
• Diabetic Cardiovascular Protection: Specialized care for diabetic patients with hypertension

Heart Failure Management: BISOZIO 5mg plays a crucial role in heart failure treatment by reducing the heart's workload and improving cardiac efficiency. In patients with heart failure with reduced ejection fraction (HFrEF), this medication helps the heart pump more effectively and can significantly improve survival rates.

Long-term Cardiovascular Benefits: Regular use of BISOZIO 5mg provides comprehensive cardiovascular protection including reduced risk of sudden cardiac death, prevention of heart attack recurrence, improved exercise tolerance, and enhanced quality of life for patients with chronic cardiovascular conditions.

Metabolic Advantages: Unlike some other beta-blockers, Bisoprolol at 5mg strength has minimal impact on glucose metabolism, making it particularly suitable for diabetic patients requiring cardiovascular protection.

• Standard Maintenance Dose: 5 mg once daily, preferably in the morning
• Hypertension Management: May be increased to 10mg daily if additional control needed
• Heart Failure Therapy: Carefully titrated maintenance dose under specialist supervision
• Timing: Consistent daily administration for optimal therapeutic effect
• Food Interaction: Can be taken with or without food for patient convenience
• Elderly Patients: May require dose adjustment based on response and tolerability

Common Side Effects at 5mg dose:

• Bradycardia (slow heart rate) - monitor heart rate regularly
• Mild dizziness especially during dose initiation
• Fatigue that typically improves with continued therapy
• Cold extremities due to reduced peripheral circulation
• Gastrointestinal effects (nausea, diarrhea, constipation)

Serious Conditions Requiring Immediate Medical Attention:

• Heart rate below 50 beats per minute
• Severe breathing difficulties or wheezing
• Signs of worsening heart failure (leg swelling, shortness of breath)
• Chest pain or irregular heartbeat
• Severe allergic reactions (rash, swelling, difficulty breathing)